In the present work, fast disintegrating tablets of Caffeine were prepared by subliming method with a view to enhance patient compliance.Initially solid dispersion of caffeine was prepared by using beta cyclodextrin. two super-disintegrants, viz., crospovidone and Microcrystalline cellulose were with camphor as subliming agent. The prepared batches of tablets were evaluated for thickness, weigh variation, hardness, friability, drug content uniformity, wetting time, water absorption ratio, in-vitro disintegration time and in-vitro drug release. Six formulations were tested for the in-vitro drug release pattern (in pH 6.8 phosphate buffer). Among the six promising formulations, the formulation F5 prepared by using 10 mg of crospovidone and 25 mg of camphor and emerged as the overall best formulation based on the in-vitro drug release characteristics.
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